The Role of Contrast Ultrasound in Liver Interventions


Since the spring of 2016, the growth of ultrasound in the United States has erupted with the FDA approval of contrast for liver examinations. The contrast agents used for ultrasound consist of very small bubbles of gas surrounded by a fatty shell. These are smaller than red blood cells, so they can pass through the lungs safely. It is injected into the vascular system and does not filter through the kidneys or cause a contrast reaction that may be seen with CT or MRI contrast agents. The introduction of these micro-bubbles has allowed the visualization of the tiny vessels in the parenchyma of the liver that was previously only studied with B mode and Doppler techniques with limited success. These tiny bubbles are confined to the vascular space, making them a bit different than CT and MRI contrast agents, which rapidly clear from the blood pool into the extravascular space.1

Key advantages and disadvantages to using Contrast Enhanced Ultrasound

According to the Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver - Updated 20121, advantages and disadvantages of the clinical use of contrast in the liver include:

Advantages of Ultrasound Contrast

  • Real-time ultrasound to visualize the characteristics of a lesion as it fills with blood
  • The perfusion of the organ and increased visualization of main vessels
  • Guidance for difficult-to-see lesions
  • Ability to be re-administered repeatedly in the same session

Disadvantages of Ultrasound Contrast

  • Fatty infiltration can be a limiting factor for penetrating to see deep lesions
  • The image quality of the baseline ultrasound is comparable to the quality of the contrast-enhanced ultrasound
  • The smallest lesions detectible range from 3-5mm

Interventional Guidance Using Ultrasound

Ultrasound contrast can assist during interventional procedures in several ways.

For example:

  1. Improve the visualization of difficult-to-see liver lesions enabling ultrasound-guided biopsy1
  2. As a visual aid to help in the treatment of liver abnormalities
    • Radiofrequency ablation can be performed with the use of contrast ultrasound to picture borders better for a more complete ablation1
    • Contrast-enhanced ultrasound can be combined with fusion imaging as a follow-up tool to ensure complete lesion destruction is obtained1

CEUS paired with US/MR fusion of the liver post ablation to access adequate destruction of the lesion.2

liver abscess

Pictured above is an example of contrast used for a drain placement in the treatment of a liver abscess.3

3. In the case of early hepatocellular carcinoma, also referred to as HCC, transplantation or resection can be curative, with the help of intraoperative ultrasound. Contrast can be an integral part of intraoperative ultrasound lesion detection.1 Below is a case of a patient with HCC that was appreciated on MRI, and during surgery, ultrasound could not adequately image the lesion until contrast was administered. Resection was successfully performed.

MRI Ultrasound

Pictured above is an example of contrast used for a drain placement in the treatment of a liver abscess.4

Whether it be contrast-enhanced ultrasound-guided biopsy, fusion, radiofrequency ablation or surgery, CIVCO has many products that can aid in an efficient procedure.

PEELSafe AdvantageChoose one of our sterile probe covers to protect both the probe and patient from contamination during an intervention. There is no need to apply any gel to the probe before covering it within the PEELSafe Advantage™ cover, which decreases preparation time and clean-up. For more information about PEELSafe Advantage click here.

CIVCO offers needle guidance solutions to assist during ultrasound-guided procedures. Electromagnetic needle tracking is an effective tool to access difficult anatomy not easily visible under conventional ultrasound. Visit our case study library on CIVCOmmunity for more examples of how to needle tracking can add value during interventions.


The next generation of guidance offered by CIVCO is the Verza™ Guidance System.

It offers:

  • Improved needle visualization
  • Five-angles of approach
  • Decreased blind-zone
  • Increased stability during the procedure
  • Quick release feature for improved workflow


  1. Claudon, Michel. "Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound in the Liver Update 2012." Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound in the Liver Update 2012, pp. 188-210.,
  2. Zheng. "Improvement of Ablative Margins by the Intraoperative Use of CEUS-CT/MR Image Fusion in Hepatocellular Carcinoma." BMC Cancer, BioMed Central, 18 Apr. 2016,
  3. Patel, K. "Breaking Dawn - Novel Uses of Contrast-Enhanced Ultrasound (CEUS) in Radiological Intervention ." Electronic Presentation Online System , 2013,
  4. Joo, and Ijin. "The Role of Intraoperative Ultrasonography in the Diagnosis and Management of Focal Hepatic Lesions." Ultrasonography, Korean Society of Ultrasound in Medicine,